Which type of cell is responsible for the uptake of amino acid neurotransmitters in the brain?

Astrocytes play a critical role in the uptake of amino acid neurotransmitters in the brain. These glial cells are strategically located throughout the central nervous system and have numerous processes that extend to neuronal synapses.

One of their key functions is to regulate the extracellular environment of neurons, which includes the removal of excess neurotransmitters after synaptic transmission. Specifically, astrocytes possess transporters for several amino acid neurotransmitters, such as glutamate and glycine. By uptake and converting these neurotransmitters, astrocytes help to terminate the signaling at synapses and prevent excitotoxicity, thereby contributing to overall brain homeostasis.

This function is crucial for maintaining proper communication between neurons and ensuring that neurotransmitter levels are balanced, which influences neuronal health and function.